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A study has uncovered a brain-related pathway for how metformin -- the first-line treatment for diabetes for over 60 years and not considered to target the brain -- regulates blood sugar, opening the door to more targeted therapies. "It's been widely accepted that metformin lowers blood glucose primarily by reducing glucose output in the liver. [...]

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A new study reveals metformin acts directly on the brain, raising fresh concerns about its wider effects. While effective for diabetes, experts warn of potential cognitive, neurological and metabolic risks, especially with long-term or unsupervised u

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A study reveals metformin influences brain pathways to regulate blood sugar, potentially leading to new diabetes treatments targeting the brain.

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While diabetes medications are not considered as targeting the brain, the study, published in the journal Science Advances, shows that metformin has been influencing brain pathways all along, the researchers said.

Metformin, a long-standing treatment for type 2 diabetes, may also work directly in the brain, according to new research. The study highlights how the drug affects specific brain pathways, offering a fresh understanding of its role in glucose regulation.